HPV Mutation Detail Information

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Mutation Information

Mutation Site	H78Y
Mutation Type	Amino acid level
Gene/Protein/Region Type	E6
Amino acid_Mutation	C335T
Genotype/Subtype	HPV16
Viral Reference	NC 001526
Country	China

Literature Information

PubMed PMID	27038009
Disease	Cervical intraepithelial neoplasia
Published Year	2016
Journal	Journal of medical virology
Title	Association between human papillomavirus type 16 E6 and E7 variants with subsequent persistent infection and recurrence of cervical high-grade squamous intraepithelial lesion after conization.
Author	Zhang L,Yang B,Zhang A,Zhou A,Yuan J,Wang Y,Sun L,Cao H,Wang J,Zheng W
Evidence	We found that the total genetic variation was as follows: missense mutations D25E(T178G), H78Y(C335T), L83V(T350G), E113D(A442C); and synonymous mutations A131C in E6; and missense mutations A646C (N29H), A647G (N29S), synonymous mutations T846C (S95S) in E7.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation