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Mutation Information
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Mutation Site
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H71R |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpr |
Literature Information
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PubMed PMID
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33811831
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Published Year
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2021 |
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Journal
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Cell host & microbe |
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Title
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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr. |
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Author
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Dupont L,Bloor S,Williamson JC,Cuesta SM,Shah R,Teixeira-Silva A,Naamati A,Greenwood EJD,Sarafianos SG,Matheson NJ,Lehner PJ |
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Evidence
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Indeed, two Vpr point mutants, which are unable to bind the ligase adaptor protein DCAF1, Q65R Vpr, and H71R Vpr, failed to increase unintegrated virus expression (Figure 1G)
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HIV Mutation Detail Information