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Mutation Information

Mutation Site	H48N
Mutation Type	Amino acid level
Gene/Protein/Region Type	Vif

Literature Information

PubMed PMID	32446377
Published Year	2020
Journal	Biochemical and biophysical research communications
Title	Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest.
Author	Nagata K,Shindo K,Matsui Y,Shirakawa K,Takaori-Kondo A
Evidence	We further examined the potency of Vif mutants for cell cycle arrest induction and PPP2R5D degradation in CEM-SS cells. NL4-3 Vif R33K, N48H, and T47P/K50R induced G2 arrest in CEM-SS cells comparably to NL4-3 Vif wild-type, but I31V/R33G did not (Fig. 4D).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation