HIV Mutation Detail Information

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Mutation Information

Mutation Site	H375T
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Genotype/Subtype	A;B;C;D;F;CRF02_AG
Viral Reference	AF038399.1
Country	Montreal and canda

Literature Information

PubMed PMID	32457241
Disease	HIV infection/AIDS
Published Year	2020
Journal	mBio
Title	The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.
Author	Prévost J,Tolbert WD,Medjahed H,Sherburn RT,Madani N,Zoubchenok D,Gendron-Lepage G,Gaffney AE,Grenier MC,Kirk S,Vergara N,Han C,Mann BT,Chénine AL,Ahmed A,Chaiken I,Kirchhoff F,Hahn BH,Haim H,Abrams CF,Smith AB 3rd,Sodroski J,Pazgier M,Finzi A
Evidence	The H375S/T mutation most likely induces a loss in stability of the CD4 binding pocket in the absence of CD4 or CD4mc that in LM variants is partially compensated for by the Ile475-to-Met mutation.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation