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Mutation Information
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Mutation Site
|
H308T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Gp120 |
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Country
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US |
Literature Information
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PubMed PMID
|
32156815
|
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Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
mBio |
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Title
|
Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants. |
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Author
|
Martinez DR,Tu JJ,Kumar A,Mangold JF,Mangan RJ,Goswami R,Giorgi EE,Chen J,Mengual M,Douglas AO,Heimsath H,Saunders KO,Nicely NI,Eudailey J,Hernandez G,Morgan-Asiedu PK,Wiehe K,Haynes BF,Moody MA,LaBranche C,Montefiori DC,Gao F,Permar SR |
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Evidence
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The binding activity of V3-specific IgG MAb H650129 obtained from transmitting woman 3902 was ablated by N-terminal K305Q I307T H308T and K305A I307A mutations and C-terminal F317A A319K D322A, F317L A319T D322R, F317A, and A319K mutations, suggesting that H650129 requires both N- and C-terminal amino acid residues for binding.
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HIV Mutation Detail Information