Mutation Information
Mutation Site
|
H29Y |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Tat |
Country
|
India |
Literature Information
PubMed PMID
|
24465566
|
Disease
|
HIV infection/AIDS
|
Published Year
|
2014 |
Journal
|
PloS one |
Title
|
Molecular and genetic characterization of natural HIV-1 Tat Exon-1 variants from North India and their functional implications. |
Author
|
Ronsard L,Lata S,Singh J,Ramachandran VG,Das S,Banerjea AC |
Evidence
|
Despite high amino acid conservation, some interesting mutations were observed in various functional domains which included K24T, H29Y and L35P mutations in cysteine-rich region with 1.000, 1.000 and 0.333 allelic frequencies respectively; G44S and S46F mutations in the core region with 30% and 20% of variants respectively; P68L mutation in all variants in the glutamine rich region which was neither seen with Tat B nor Tat C consensus sequences.
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