HPV Mutation Detail Information

> H252L Search Result


Mutation Information
Mutation Site H252L
Mutation Type Amino acid level
Gene/Protein/Region Type E2
Amino acid_Mutation A3509T
Genotype/Subtype HPV16
Viral Reference K02718; AF536179; HQ644236; AF534061; AF536180; HQ644298; AF472509; HQ644257; AY686579; AF402678
Country Poland
Literature Information
PubMed PMID 33909391
Disease Low grade squamous intraepithelial lesion
Published Year 2021
Journal Acta biochimica Polonica
Title Sequence variation analysis of the E1 and E2 genes of human papillomavirus type 16 in cervical lesions in women from the south of Poland.
Author Sitarz K,Kopec J,Zawilinska B,Klimek M,Szostek S
Evidence The sequence analysis showed 27 substitutions at 25 nucleotides located between positions 2815 and 3766 (A2815G, T2817G, C2833T, T2835G, C2839A, T2841A, C2876G, C2876T T2877A, T2881G, T2881A, A2885T, A2910C, A2918T, G3187T, C3401A, C3409T, C3461T, C3464T, A3509T, T3523G, G3533T, A3534C, C3535T, C3573A, A3691G, G3766A) leading to an amino acid change (N21E, R27W, H29K, A41G, A41V, Y43D, Y43N, Y44F, K52N, N55I, V145L, A216E, P219S, T236M, T237I, H252L, L257V, D260S, S261L, S273R, T313A, D338N), while other nucleotide substitutions (C2892G, C2922T, A2937G, A3024G, A3186T, C3408T, C3438A, A3454T, C3504T, T3560G) were silent or encoded the STOP codon (C2948G, A2950T).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation