HIV Mutation Detail Information

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Mutation Information

Mutation Site	H221Y
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Country	USA

Literature Information

PubMed PMID	30305383
Disease	HIV infection/AIDS
Published Year	2018
Journal	Journal of clinical microbiology
Title	Limited Marginal Utility of Deep Sequencing for HIV Drug Resistance Testing in the Age of Integrase Inhibitors.
Author	Dalmat RR,Makhsous N,Pepper GG,Magaret A,Jerome KR,Wald A,Greninger AL
Evidence	In three other Pr-RT tests, Sanger reported mutations that were detected at less than 20% allele frequency by NGS: V108I was called by HyDRA (15.9%) and PASeq (17.1%) (7.0%), and H221Y was called by HyDRA (17.9%) and PASeq (17.7%) (Fig. 3C). These results demonstrate that DRMs at allele frequencies under 20% can be detected by Sanger sequencing.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation