HIV Mutation Detail Information

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Mutation Information

Mutation Site	H219Q
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gag
Country	Durban; South Africa

Literature Information

PubMed PMID	18369479
Disease	HIV infection/AIDS
Published Year	2008
Journal	PLoS pathogens
Title	Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
Author	Chopera DR,Woodman Z,Mlisana K,Mlotshwa M,Martin DP,Seoighe C,Treurnicht F,de Rosa DA,Hide W,Karim SA,Gray CM,Williamson C,CAPRISA 002 Study Team.
Evidence	Viruses carrying the T242N and A146X escape mutants from two of the nine individuals (CAP045 and CAP061), also carried the H219Q compensatory mutation that has been shown to partially restore replicative fitness losses incurred by the T242N mutation.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation