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Mutation Information
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Mutation Site
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H127T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Tax |
Literature Information
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PubMed PMID
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17535428
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Published Year
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2007 |
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Journal
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Retrovirology |
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Title
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HTLV-1 Tax mutants that do not induce G1 arrest are disabled in activating the anaphase promoting complex. |
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Author
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Merling R,Chen C,Hong S,Zhang L,Liu M,Kuo YL,Giam CZ |
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Evidence
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By contrast, several mutants (C23W, P102L, A108T, A108V, H127T, L159F, 235F, G245D, and D264Y) continued to transactivate both LTR and NF-kappaB reporters to levels (greater than 50%) comparable to those of the wild-type Tax.
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HTLV1 Mutation Detail Information