HTLV1 Mutation Detail Information

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Mutation Information

Mutation Site	H127S
Mutation Type	Amino acid level
Gene/Protein/Region Type	Tax
Combined Mutation	tax.H127S+tax.Q126A

Literature Information

PubMed PMID	8970957
Published Year	1996
Journal	Journal of virology
Title	Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat.
Author	Tie F,Adya N,Greene WC,Giam CZ
Evidence	These mutants [M18 (T123A, L124S), M19 (Q126A,H127S),M24(T145A,L146S),M28(P176A,G177S),andM34(G203A,A204S)]areimpairedtodifferentextentsinthetrans-activation functions and showed,5, 120, 54, 32, and 14% ofwild-type levels of activity in transactivation of the HTLV-1LTR, respectively

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation