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Mutation Information
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Mutation Site
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G89V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
CA |
Literature Information
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PubMed PMID
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32187548
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Published Year
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2020 |
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Journal
|
Cell reports |
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Title
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Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core. |
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Author
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Selyutina A,Persaud M,Simons LM,Bulnes-Ramos A,Buffone C,Martinez-Lopez A,Scoca V,Di Nunzio F,Hiatt J,Marson A,Krogan NJ,Hultquist JF,Diaz-Griffero F |
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Evidence
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To further corroborate these findings, we challenged human PBMCs and CD4+ T cells with increasing amounts of HIV-1-GFP particles bearing the capsid mutations P90A and G89V, both of which prevent CypA-capsid interactions.
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HIV Mutation Detail Information