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Mutation Information
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Mutation Site
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G89V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
CA |
Literature Information
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PubMed PMID
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17087820
|
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Published Year
|
2006 |
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Journal
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Retrovirology |
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Title
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Human TRIM5alpha mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants. |
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Author
|
Kaumanns P,Hagmann I,Dittmar MT |
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Evidence
|
The viral capsid of HIV-1 is the main target for the antiviral effect, since certain mutations in the capsid protein (for example exchange of glycine to valine or alanine at position 89, G89V and G89A respectively) have been shown to confer resistance to TRIM5alpha mediated restriction.
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HIV Mutation Detail Information