HBV Mutation Detail Information

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Mutation Information
Mutation Site G588C
Mutation Type Nucleotide level
Gene/Protein/Region Type S
Nucleotide_Mutation G145A
Genotype/Subtype D
Immune Escape Y
Relevant Drug hepatitis B immunoglobulin (HBIG)
Country Germany
Literature Information
PubMed PMID 9425945
Disease Fulminant hepatitis B; Liver cirrhosis
Published Year 1998
Journal Hepatology (Baltimore, Md.)
Title Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation.
Author Protzer-Knolle U,Naumann U,Bartenschlager R,Berg T,Hopf U,Meyer zum Büschenfelde KH,Neuhaus P,Gerken G
Evidence In VitroTranscription and Translation of Wild-Type and Mutant S-Protein.Plasmids were selected that contained the complete S-gene of HBVwild-type or S-gene mutants nt A585G (aa sA144G; patient 340) or nt G588C (aa sG145A; patient 357).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation