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Mutation Information
|
Mutation Site
|
G48T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Combined Mutation
|
pr.L89M+pr.G48T |
|
Genotype/Subtype
|
B |
|
Relevant Drug
|
atazanavir (ATV) |
Literature Information
|
PubMed PMID
|
30560871
|
|
Published Year
|
2018 |
|
Journal
|
Scientific reports |
|
Title
|
Characterizing early drug resistance-related events using geometric ensembles from HIV protease dynamics. |
|
Author
|
Sheik Amamuddy O,Bishop NT,Tastan Bishop Ö |
|
Evidence
|
Previous work described distinct mechanisms associated with ARV drug resistance that all point to active site expansion, namely (1) impaired hydrophobic sliding shown in the G48T/L89M double mutant with saquinavir, (2) reduced dimer stability in L24I, I50V and F53L mutants and (3) single or co-operative distal mutations.
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HIV Mutation Detail Information