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Mutation Information
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Mutation Site
|
G342X |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
LMP1 |
Literature Information
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PubMed PMID
|
31481499
|
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Published Year
|
2019 |
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Journal
|
Cancer research |
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Title
|
Integrated Pan-Cancer Map of EBV-Associated Neoplasms Reveals Functional Host-Virus Interactions. |
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Author
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Chakravorty S,Yan B,Wang C,Wang L,Quaid JT,Lin CF,Briggs SD,Majumder J,Canaria DA,Chauss D,Chopra G,Olson MR,Zhao B,Afzali B,Kazemian M |
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Evidence
|
For example, one-third of EBV+ NK/T-cell lymphoma patients carried two novel nonsense variants (Q322X, G342X) of LMP1 and both variant proteins failed to restrict viral reactivation, confirming loss of virostatic function.
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EBV Mutation Detail Information