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Mutation Information
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Mutation Site
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G3187T |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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E2 |
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Nucleotide_Mutation
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V145L |
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Genotype/Subtype
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HPV16 |
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Viral Reference
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K02718;
AF536179;
HQ644236;
AF534061;
AF536180;
HQ644298;
AF472509;
HQ644257;
AY686579;
AF402678 |
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Country
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Poland |
Literature Information
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PubMed PMID
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33909391
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Disease
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Low grade squamous intraepithelial lesion
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Published Year
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2021 |
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Journal
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Acta biochimica Polonica |
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Title
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Sequence variation analysis of the E1 and E2 genes of human papillomavirus type 16 in cervical lesions in women from the south of Poland. |
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Author
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Sitarz K,Kopec J,Zawilinska B,Klimek M,Szostek S |
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Evidence
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The sequence analysis showed 27 substitutions at 25 nucleotides located between positions 2815 and 3766 (A2815G, T2817G, C2833T, T2835G, C2839A, T2841A, C2876G, C2876T T2877A, T2881G, T2881A, A2885T, A2910C, A2918T, G3187T, C3401A, C3409T, C3461T, C3464T, A3509T, T3523G, G3533T, A3534C, C3535T, C3573A, A3691G, G3766A) leading to an amino acid change (N21E, R27W, H29K, A41G, A41V, Y43D, Y43N, Y44F, K52N, N55I, V145L, A216E, P219S, T236M, T237I, H252L, L257V, D260S, S261L, S273R, T313A, D338N), while other nucleotide substitutions (C2892G, C2922T, A2937G, A3024G, A3186T, C3408T, C3438A, A3454T, C3504T, T3560G) were silent or encoded the STOP codon (C2948G, A2950T).
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HPV Mutation Detail Information