HTLV1 Mutation Detail Information

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Mutation Information

Mutation Site	G306C
Mutation Type	Nucleotide level
Gene/Protein/Region Type	5′LTR
Country	Brazil

Literature Information

PubMed PMID	26472535
Disease	HTLV-1 associated myelopathy/tropical spastic paraparesis
Published Year	2016
Journal	AIDS research and human retroviruses
Title	Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers.
Author	Rego FF,de Oliveira T,Giovanetti M,Galvão-Castro B,Gonçalves Mde S,Alcantara LC
Evidence	Although those mutations were not present in previously determined TFBS, one of those mutations (G306C/A) was present in an Sp-1 binding site determined by in silico analysis, and its presence abrogated the site for Sp-1 binding and created a new possible ATF binding site.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation