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Mutation Information
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Mutation Site
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G2A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Nef |
Literature Information
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PubMed PMID
|
33109760
|
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Published Year
|
2020 |
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Journal
|
mBio |
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Title
|
HIV-1 Nef Interacts with LMP7 To Attenuate Immunoproteasome Formation and Major Histocompatibility Complex Class I Antigen Presentation. |
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Author
|
Yang Y,Liu W,Hu D,Su R,Ji M,Huang Y,Shereen MA,Xu X,Luo Z,Zhang Q,Liu F,Wu K,Liu Y,Wu J |
|
Evidence
|
To determine the impact of Nef myristoylation on the formation of iProteasomes, the second amino acid of Nef glycine, which is critical for the myristoylation of Nef (36), was mutated to alanine (Nef-G2A).
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HIV Mutation Detail Information