|
Mutation Information
|
Mutation Site
|
G2A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Nef |
Literature Information
|
PubMed PMID
|
31736889
|
|
Published Year
|
2019 |
|
Journal
|
Frontiers in microbiology |
|
Title
|
HIV-1 Nef Targets HDAC6 to Assure Viral Production and Virus Infection. |
|
Author
|
Marrero-Hernández S,Márquez-Arce D,Cabrera-Rodríguez R,Estévez-Herrera J,Pérez-Yanes S,Barroso-González J,Madrid R,Machado JD,Blanco J,Valenzuela-Fernández A |
|
Evidence
|
Nef appears to neutralize HDAC6 by an acidic/endosomal-lysosomal processing and does not need the downregulation function, since data obtained with the non-associated cell-surface Nef-G2A mutant - the cytoplasmic location of HDAC6 - together with studies with chemical inhibitors and other Nef mutants, point to this direction.
|
|
|
HIV Mutation Detail Information