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Mutation Information
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Mutation Site
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G212S |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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LMP1 |
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Viral Reference
|
V01555.2
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Literature Information
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PubMed PMID
|
18986987
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Published Year
|
2008 |
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Journal
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The Journal of biological chemistry |
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Title
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Tumor-derived variants of Epstein-Barr virus latent membrane protein 1 induce sustained Erk activation and c-Fos. |
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Author
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Vaysberg M,Hatton O,Lambert SL,Snow AL,Wong B,Krams SM,Martinez OM |
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Evidence
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In contrast, only tumor-derived LMP1 variants induced prolonged Erk activation and c-Fos expression. Sequence analysis revealed only two amino acids, 212 and 366, shared by the tumor variants but distinct from B95.8. Point mutation of either amino acids 212 (glycine to serine) or 366 (serine to threonine) from the B95.8 isoform to the tumor variant version of LMP1 was sufficient for gain of function characterized by sustained activation of Erk and subsequent c-Fos induction and binding to the AP1 site.
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EBV Mutation Detail Information