HIV Mutation Detail Information

> G212A Search Result

Mutation Information

Mutation Site	G212A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gag

Literature Information

PubMed PMID	32709741
Published Year	2020
Journal	Proceedings of the National Academy of Sciences of the United States of America
Title	Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells.
Author	Elsner C,Ponnurangam A,Kazmierski J,Zillinger T,Jansen J,Todt D,Döhner K,Xu S,Ducroux A,Kriedemann N,Malassa A,Larsen PK,Hartmann G,Barchet W,Steinmann E,Kalinke U,Sodeik B,Goffinet C
Evidence	Reconstitution of normally cGAS-negative Jurkat T cells with WT, but not with catalytically inactive, cGAS (G212A/S213A) mutant enabled IFIT1 up-regulation as an early response to plasmid DNA challenge (SI Appendix, Fig. S5A).

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation