HIV Mutation Detail Information

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Mutation Information

Mutation Site	G190A
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Viral Reference	K03455.1
Relevant Drug	NNRTIs
Country	UK

Literature Information

PubMed PMID	18052601
Disease	HIV infection/AIDS
Published Year	2007
Journal	PLoS medicine
Title	N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance.
Author	Yap SH,Sheen CW,Fahey J,Zanin M,Tyssen D,Lima VD,Wynhoven B,Kuiper M,Sluis-Cremer N,Harrigan PR,Tachedjian G
Evidence	N348I was highly associated with several key drug resistance mutations, including M184V/I (p = 6.6 × 10−45) the TAMs M41L (p = 1.8 × 10−14), D67N (p = 7.7 × 10−10), K70R (p = 1.4 × 10−10), T215Y/F (p = 6.0 × 10−21), K219Q/E (p = 8.0 × 10−4), and L210W (p = 0.002), and the NNRTI resistance mutations K103N (p = 1.1 × 10−19), V108l (p = 8.4 × 10−13), Y181C/I (p = 4.7 × 10−13) and G190A/S (p = 8.0 × 10−9) (Figure 1).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation