Mutation Information
Mutation Site
|
G1899A |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
PreC |
Combined Mutation
|
prec.G1899A+prec.G1896A |
Country
|
Brazil |
Literature Information
PubMed PMID
|
28902288
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2017 |
Journal
|
Memorias do Instituto Oswaldo Cruz |
Title
|
Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases. |
Author
|
Chachá SGF,Gomes-Gouvêa MS,Malta FM,Ferreira SDC,Villanova MG,Souza FF,Teixeira AC,Passos ADDC,Pinho JRR,Martinelli ALC |
Evidence
|
Among the 129 patients in whom the HBV PC region was analysed, a high frequency of HBV strains with G1896A mutation (53/129, 41%) was detected, alone or in G1896A/G1899A double mutation, particularly in the subgroup with HBeAg-negative chronic hepatitis (39/85, 45.9%) (p = 0.03).
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