Mutation Information
Mutation Site
|
G1899A |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
PreC |
Genotype/Subtype
|
B;C |
Country
|
China |
Literature Information
PubMed PMID
|
24006435
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2013 |
Journal
|
Journal of virology |
Title
|
HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations. |
Author
|
Zhang Q,Yin J,Zhang Y,Deng Y,Ji X,Du Y,Pu R,Han Y,Zhao J,Han X,Zhang H,Cao G |
Evidence
|
Table 3 lists the HBV mutations in the EnhII/BCP/PC region that are significantly associated with HC and HCC. Of these, the C1653T, T1753C, A1762T/G1764A, and G1899A mutations in HBV genotype C and the A1762T/G1764A mutations in HBV genotype B increased in prevalence from the ASC state to HCC successively (Ptrend < 0.001 for each).
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