Mutation Information
Mutation Site
|
G1896A |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
PreC |
Country
|
Greek |
Literature Information
PubMed PMID
|
9751010
|
Disease
|
Chronic hepatitis B
|
Published Year
|
1998 |
Journal
|
Journal of viral hepatitis |
Title
|
Incidence and clinical significance of hepatitis B virus precore gene translation initiation mutations in e antigen-negative patients. |
Author
|
Laras A,Koskinas J,Avgidis K,Hadziyannis SJ |
Evidence
|
These data show that a significant proportion of HBeAg-negative patients who already harbour the 1896 stop codon mutation may subsequently develop precore translation initiation mutations, which appear to be associated with enhanced HBV replication and severe liver disease.
|
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