Mutation Information
Mutation Site
|
G1896A |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
PreC |
Literature Information
PubMed PMID
|
32760388
|
Published Year
|
2020 |
Journal
|
Frontiers in microbiology |
Title
|
Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants. |
Author
|
Lau KCK,Joshi SS,Mahoney DJ,Mason AL,van Marle G,Osiowy C,Coffin CS |
Evidence
|
HBV variants, particularly the G1896A pre-core (PC) and A1762T/G1764A basal core promoter (BCP) mutations, are established risk factors for cirrhosis and HCC, but the molecular biological basis is unclear.
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