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Mutation Information
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Mutation Site
|
G1896A |
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Mutation Type
|
Nucleotide level |
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Gene/Protein/Region Type
|
PreC |
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Genotype/Subtype
|
C |
|
Country
|
Korean |
Literature Information
|
PubMed PMID
|
31402915
|
|
Disease
|
HBV associated liver disease
|
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Published Year
|
2019 |
|
Journal
|
Frontiers in immunology |
|
Title
|
rt269I Type of Hepatitis B Virus (HBV) Leads to HBV e Antigen Negative Infections and Liver Disease Progression via Mitochondrial Stress Mediated Type I Interferon Production in Chronic Patients With Genotype C Infections. |
|
Author
|
Lee SY,Choi YM,Oh SJ,Yang SB,Lee J,Choe WH,Kook YH,Kim BJ |
|
Evidence
|
Of the various HBV mutations, G1896A mutations on the pre-core region (preC mutation) and A1762T/G1764A double mutations on the basal core promoter (BCP) lead to HBeAg negative infection that are significantly related to liver disease progression.
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HBV Mutation Detail Information