|
Mutation Information
|
Mutation Site
|
G1896A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreC |
|
Combined Mutation
|
prec.G1896A+bcp.G1764A+bcp.A1762T |
Literature Information
|
PubMed PMID
|
26984835
|
|
Disease
|
Acute on chronic liver failure;
Chronic hepatitis B
|
|
Published Year
|
2016 |
|
Journal
|
Hepatology international |
|
Title
|
Association between hepatitis B virus basal core promoter/precore region mutations and the risk of hepatitis B-related acute-on-chronic liver failure in the Chinese population: an updated meta-analysis. |
|
Author
|
Nian X,Xu Z,Liu Y,Chen J,Li X,Xu D |
|
Evidence
|
RESULTS: Data for 13 studies with a total of 1,149 HB-ACLF and 1,867 chronic hepatitis B (CHB) cases were retrieved. Statistically significant summary ORs for HB-ACLF were obtained for T1753V (1.99; 95 % confidence interval 1.30-3.02) and A1762T/G1764A (2.11; 95 %, 1.75-2.54) in the BCP region and for A1846T (3.33; 95 %, 2.23-4.97), G1896A (2.78; 95 %, 2.07-3.74), and G1899A (3.09; 95 %, 1.82-5.25) in the PC region.
|
|
|
HBV Mutation Detail Information