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Mutation Information
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Mutation Site
|
G1896A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreC |
|
Country
|
Iran |
Literature Information
|
PubMed PMID
|
25788956
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2015 |
|
Journal
|
Hepatitis monthly |
|
Title
|
Association of Mutations in the Basal Core Promoter and Pre-core Regions of the Hepatitis B Viral Genome and Longitudinal Changes in HBV Level in HBeAg Negative Individuals: Results From a Cohort Study in Northern Iran. |
|
Author
|
Besharat S,Poustchi H,Mohamadkhani A,Katoonizadeh A,Moradi A,Roshandel G,Freedman ND,Malekzadeh R |
|
Evidence
|
CONCLUSIONS: In this population with chronic HBeAg negative hepatitis B, an association was observed between the G1896A mutation in the Pre-core region of HBV and subsequent level of HBV DNA seven years later, which indicated that mutations in this region of HBV genome may contribute to disease progression in these patients and play an important role in HBV natural course of disease.
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HBV Mutation Detail Information