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Mutation Information
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Mutation Site
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G1896A |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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PreC |
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Country
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China |
Literature Information
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PubMed PMID
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25501679
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Disease
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Hepatocellular carcinoma
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Published Year
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2015 |
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Journal
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Clinical and experimental medicine |
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Title
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Association between HBV Pre-S mutations and the intracellular HBV DNAs in HBsAg-positive hepatocellular carcinoma in China. |
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Author
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Wang H,Wang AH,Gressner OA,Fang M,Gu X,Ji Q,Cheng SQ,Shen F,Gao CF |
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Evidence
|
The most frequent (>50 %) mutations were located at the X gene, Pre-S and Pre-C. In HBeAg-negative (−) patients, the prevalence of precore G1896A and core A2159G mutants was significantly higher than those in the HBeAg (+) patients (G1896A: 84 vs. 31 %, P = 0.001; A2159G: 45 vs. 17 %, P = 0.004. Fig. 1c).
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HBV Mutation Detail Information