Mutation Information
Mutation Site
|
G1896A |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
PreC |
Genotype/Subtype
|
B |
Country
|
Japan |
Literature Information
PubMed PMID
|
19850315
|
Disease
|
Fulminant hepatitis B
|
Published Year
|
2009 |
Journal
|
Virology |
Title
|
Enhanced intracellular retention of a hepatitis B virus strain associated with fulminant hepatitis. |
Author
|
Inoue J,Ueno Y,Nagasaki F,Wakui Y,Kondo Y,Fukushima K,Niitsuma H,Shimosegawa T |
Evidence
|
The pBFH2 construct with A1762T/G1764A, G1862T, and G1896A showed the largest amount of core particle-associated intracellular HBV DNA, but no significant increase of extracellular HBV DNA in comparison with the wild construct, suggesting that these mutations might work together for retention of the replicative intermediates in the cells.
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