|
Mutation Information
|
Mutation Site
|
G1896A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreC |
|
Combined Mutation
|
prec.G1896A+bcp.G1764A+bcp.A1762T |
|
Genotype/Subtype
|
E |
|
Viral Reference
|
X75658;
X75664 |
|
Country
|
Gambia |
Literature Information
|
PubMed PMID
|
18508941
|
|
Disease
|
Liver cirrhosis;
Hepatocellular carcinoma
|
|
Published Year
|
2008 |
|
Journal
|
Journal of clinical microbiology |
|
Title
|
Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus. |
|
Author
|
Mendy ME,Kaye S,Le Roux E,Kirk GD,Jeng-Barry A,McConkey S,Cotten M,Kuniholm MH,Leligdowicz A,Hainaut P,Rowland-Jones S,Whittle H |
|
Evidence
|
Persistent hepatitis B virus (HBV) infection is a major cause of these diseases. Double mutations in the basal core promoter (BCP) (A1762T and G1764A) and precore (pre-C) (G1896A) regions of the virus are associated with progression to HCC.
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HBV Mutation Detail Information