|
Mutation Information
|
Mutation Site
|
G1896A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreC |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
interferon (IFN) |
|
Country
|
japan |
Literature Information
|
PubMed PMID
|
14654974
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2004 |
|
Journal
|
International journal of molecular medicine |
|
Title
|
Early response to interferon alpha treatment and long-term clinical outcome in Japanese patients with chronic HBV genotype C infection. |
|
Author
|
Seo Y,Yoon S,Hamano K,Nakaji M,Yano Y,Katayama M,Ninomiya T,Hayashi Y,Kasuga M |
|
Evidence
|
Although not significant, responders tended to have younger age, a higher serum transaminase level, a lower frequency of precore mutation (G1896A) (67% vs. 92%) and a higher frequency of core promoter mutation (A1762T/G1764A) (89% vs. 58%) than non-responders.
|
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HBV Mutation Detail Information