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Mutation Information
|
Mutation Site
|
G1862T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
PreC |
|
Combined Mutation
|
prec.G1896A+prec.G1862T |
|
Genotype/Subtype
|
A |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
28902288
|
|
Disease
|
Chronic hepatitis B;
Hepatocellular carcinoma;
Liver cirrhosis
|
|
Published Year
|
2017 |
|
Journal
|
Memorias do Instituto Oswaldo Cruz |
|
Title
|
Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases. |
|
Author
|
Chachá SGF,Gomes-Gouvêa MS,Malta FM,Ferreira SDC,Villanova MG,Souza FF,Teixeira AC,Passos ADDC,Pinho JRR,Martinelli ALC |
|
Evidence
|
Among patients with HBV genotype D, the PC mutation G1896A was detected in 84.1% of the cases (53/63), while the G1862T mutation was detected in 92.3% of the subjects infected with HBV genotype A (36/39) (p < 0.01).
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HBV Mutation Detail Information