|
Mutation Information
|
Mutation Site
|
G176A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
E6 |
|
Nucleotide_Mutation
|
D59N |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
K02718.1
|
|
Country
|
Argentina |
Literature Information
|
PubMed PMID
|
25735347
|
|
Disease
|
High grade squamous intraepithelial lesion
|
|
Published Year
|
2015 |
|
Journal
|
Asian Pacific journal of cancer prevention : APJCP |
|
Title
|
Mutation detection of E6 and LCR genes from HPV 16 associated with carcinogenesis. |
|
Author
|
Mosmann JP,Monetti MS,Frutos MC,Kiguen AX,Venezuela RF,Cuffini CG |
|
Evidence
|
Importantly, while changes in E6 resulted in amino acid changes, G176A variation produced a change of negative amino acids for polar amino acids, which could modify the protein biological activity (Table 2).
|
|
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HPV Mutation Detail Information