|
Mutation Information
|
Mutation Site
|
G1764A |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
BCP |
|
Combined Mutation
|
bcp.G1764A+bcp.A1762T |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
29248936
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2017 |
|
Journal
|
Medical science monitor : international medical journal of experimental and clinical research |
|
Title
|
Patients with Coexistence of Circulating Hepatitis B Surface Antigen and Its Antibody May Have a Strong Predisposition to Virus Reactivation During Immunosuppressive Therapy: A Hypothesis. |
|
Author
|
Chen YL,Mo YQ,Zheng DH,Ma JD,Jing J,Dai L |
|
Evidence
|
Recent studies have shown that the uncommon serological pattern of coexistent circulating HBV surface antigen (HBsAg) and its antibody (anti-HBs) was associated with double mutations (A1762T/G1764A) in the basal core promoter (BCP) region of the HBV genome, which is critical for HBV replication.
|
|
|
HBV Mutation Detail Information