HBV Mutation Detail Information

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Mutation Information

Mutation Site	G1764A
Mutation Type	Nucleotide level
Gene/Protein/Region Type	C Promoter
Combined Mutation	c promoter.G1764A+c promoter.A1762T;c promoter.C1766T+c promoter.G1764A+c promoter.A1762T+c promoter.T1753C
Genotype/Subtype	A

Literature Information

PubMed PMID	17627632
Disease	Chronic hepatitis B
Published Year	2007
Journal	Hepatology research : the official journal of the Japan Society of Hepatology
Title	Impact of viral genotypes and naturally occurring mutations on biological properties of hepatitis B virus.
Author	Tong S
Evidence	We found that the hot spot mutations (A1762T/G1764A) only mildly reduced HBeAg expression and enhanced genome replication, while incorporation of additional core promoter mutations intensified both phenotypes.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation