HBV Mutation Detail Information

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Mutation Information

Mutation Site	G145R
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Amino acid_Mutation	G587A

Literature Information

PubMed PMID	9303514
Clinical information	Yes
Disease	Fulminant hepatitis B; Acute hepatitis B
Published Year	1997
Journal	Hepatology (Baltimore, Md.)
Title	Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis.
Author	Hsu HY,Chang MH,Ni YH,Lin HH,Wang SM,Chen DS
Evidence	An S mutant (residue 126, Thr to Ala) initially found in an infant with fulminant hepatitis was replaced by another S mutant (residue 145, Gly to Arg) 4 days later. In a girl withChronic hepatitis B, Ala-126 variant and Arg-145 variant were found at 17 and 25 months of age, respectively.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation