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Mutation Information
|
Mutation Site
|
G145R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Relevant Drug
|
hepatitis B immunoglobulin (HBIG) |
Literature Information
|
PubMed PMID
|
28870397
|
|
Published Year
|
2017 |
|
Journal
|
Biologicals : journal of the International Association of Biological Standardization |
|
Title
|
Eradicating hepatitis B virus: The critical role of preventing perinatal transmission. |
|
Author
|
Stevens CE,Toy P,Kamili S,Taylor PE,Tong MJ,Xia GL,Vyas GN |
|
Evidence
|
New analyses of our data from US trials of HBIG and HBV vaccine in high-risk infants revealed better efficacy with yeast-recombinant vaccine than plasma-derived vaccine, especially in preventing late onset infections, with evidence that vaccine prevented transmission of maternal HBV infection with the glycine to arginine mutation in surface antigen codon 145 (sG145R).
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HBV Mutation Detail Information