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Mutation Information
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Mutation Site
|
G145R |
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Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
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Genotype/Subtype
|
B |
|
Viral Reference
|
AB713527.1
|
|
Immune Escape
|
Y |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
26202119
|
|
Disease
|
HBV infection
|
|
Published Year
|
2015 |
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Journal
|
Journal of clinical microbiology |
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Title
|
Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients. |
|
Author
|
Yamani LN,Yano Y,Utsumi T,Juniastuti,Wandono H,Widjanarko D,Triantanoe A,Wasityastuti W,Liang Y,Okada R,Tanahashi T,Murakami Y,Azuma T,Soetjipto,Lusida MI,Hayashi Y |
|
Evidence
|
The most frequent MHR variants related to immune evasion in the major and intermediate populations were P120Q/T, T123A, P127T, Q129H/R, M133L/T, and G145R. The major population of MHR variants causing impaired of HBsAg secretion (e.g., G119R, Q129R, T140I, and G145R) was detected only in advanced liver disease patients.
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HBV Mutation Detail Information