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Mutation Information
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Mutation Site
|
G145R |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
S |
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Country
|
Spain |
Literature Information
|
PubMed PMID
|
18167643
|
|
Disease
|
HBV-HIV coinfection
|
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Published Year
|
2007 |
|
Journal
|
Journal of acquired immune deficiency syndromes (1999) |
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Title
|
Selection of hepatitis B virus (HBV) vaccine escape mutants in HBV-infected and HBV/HIV-coinfected patients failing antiretroviral drugs with anti-HBV activity. |
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Author
|
Sheldon J,Ramos B,Garcia-Samaniego J,Rios P,Bartholomeusz A,Romero M,Locarnini S,Zoulim F,Soriano V |
|
Evidence
|
This triple mutant causes 2 amino acid changes in the overlapping surface gene (sE164D + sI195M), reducing its anti-HBs binding to levels seen only with the vaccine escape mutant sG145R.
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HBV Mutation Detail Information