|
Mutation Information
|
Mutation Site
|
G145R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Immune Escape
|
Y |
|
Relevant Drug
|
hepatitis B immunoglobulin (HBIG) |
Literature Information
|
PubMed PMID
|
12885906
|
|
Published Year
|
2003 |
|
Journal
|
Journal of virology |
|
Title
|
Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions. |
|
Author
|
Schilling R,Ijaz S,Davidoff M,Lee JY,Locarnini S,Williams R,Naoumov NV |
|
Evidence
|
The specificity of intracellular HBsAg- anti-HBs interaction was further investigated in cells transfected with HBV genomes expressing wild-type HBsAg or immune escape HBsAg (with a G145R mutation).
|
|
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HBV Mutation Detail Information