|
Mutation Information
|
Mutation Site
|
G145R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Immune Escape
|
Y |
|
Relevant Drug
|
hepatitis B immunoglobulin (HBIG) |
Literature Information
|
PubMed PMID
|
10430358
|
|
Disease
|
HBV infection
|
|
Published Year
|
1999 |
|
Journal
|
Hepato-gastroenterology |
|
Title
|
Liver graft infection by HBV S-gene mutants in transplant patients receiving long-term HBIg prophylaxis. |
|
Author
|
Santantonio T,Gunther S,Sterneck M,Rendina M,Messner M,Launois B,Francavilla A,Pastore G,Will H |
|
Evidence
|
CONCLUSIONS: These data demonstrate that long-term polyclonal anti-HBs immunoprophylaxis selected the most commonly described G145R S-gene escape HBV variant which became the dominant virus population and was responsible for graft infection.
|
|
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HBV Mutation Detail Information