HBV Mutation Detail Information

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Mutation Information
Mutation Site G145R
Mutation Type Amino acid level
Gene/Protein/Region Type S
Relevant Drug lamivudine (LAM);ganciclovir (GCV)
Country China
Literature Information
PubMed PMID 10320044
Disease Liver cirrhosis
Published Year 1999
Journal Antiviral research
Title Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the 'a' epitope of the surface antigen are sensitive to ganciclovir.
Author Oon CJ,Chen WN,Lim N,Koh S,Lim GK,Leong AL,Tan GS
Evidence Both the wild type HBV and lamivudine-related mutants with the Gly145-->Arg145 HBsAg mutation were suppressed following ganciclovir treatment, indicating a beneficial additive effect of both drugs against different forms of HBV mutants.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation