|
Mutation Information
|
Mutation Site
|
G145K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Amino acid_Mutation
|
G588A |
|
Genotype/Subtype
|
D |
|
Immune Escape
|
Y |
|
Relevant Drug
|
hepatitis B immunoglobulin (HBIG) |
|
Country
|
Germany |
Literature Information
|
PubMed PMID
|
9425945
|
|
Disease
|
Fulminant hepatitis B;
Liver cirrhosis
|
|
Published Year
|
1998 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation. |
|
Author
|
Protzer-Knolle U,Naumann U,Bartenschlager R,Berg T,Hopf U,Meyer zum Büschenfelde KH,Neuhaus P,Gerken G |
|
Evidence
|
In addition to already-known variants sG145R/K/E, we could demonstrate that newly described variants sX144G and sG145A were antigenically altered and showed impaired recognition by polyclonal HBIG in vitro.
|
|
|
HBV Mutation Detail Information