HBV Mutation Detail Information

> G145E Search Result


Mutation Information
Mutation Site G145E
Mutation Type Amino acid level
Gene/Protein/Region Type S
Genotype/Subtype D
Immune Escape Y
Relevant Drug hepatitis B immunoglobulin (HBIG)
Country Germany
Literature Information
PubMed PMID 9425945
Disease Fulminant hepatitis B; Liver cirrhosis
Published Year 1998
Journal Hepatology (Baltimore, Md.)
Title Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation.
Author Protzer-Knolle U,Naumann U,Bartenschlager R,Berg T,Hopf U,Meyer zum Büschenfelde KH,Neuhaus P,Gerken G
Evidence In addition to already-known variants sG145R/K/E, we could demonstrate that newly described variants sX144G and sG145A were antigenically altered and showed impaired recognition by polyclonal HBIG in vitro.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation