HBV Mutation Detail Information

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Mutation Information

Mutation Site	G145A
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Immune Escape	Y
Country	Japan

Literature Information

PubMed PMID	11208474
Disease	HBV infection
Published Year	2000
Journal	Medical science monitor : international medical journal of experimental and clinical research
Title	Analysis of HBs antigen negative variant of hepatitis B virus: unique substitutions, Glu129 to Asp and Gly145 to Ala in the surface antigen gene.
Author	Koyanagi T,Nakamuta M,Sakai H,Sugimoto R,Enjoji M,Koto K,Iwamoto H,Kumazawa T,Mukaide M,Nawata H
Evidence	Rare substitution was identified both at positions 129 (glutamine to asparagine) and at position 145 (glycine to alanine) in the 'a' determinant region, which is considered to be within a larger antigenic area known as the major hydrophilic region (MHR).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation