HIV Mutation Detail Information

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Mutation Information

Mutation Site	G140S
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Combined Mutation	in.G140S+in.Q148H

Literature Information

PubMed PMID	31761656
Published Year	2020
Journal	Bioorganic & medicinal chemistry letters
Title	Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Author	Peese KM,Naidu BN,Patel M,Li C,Langley DR,Terry B,Protack T,Gali V,Lin Z,Samanta HK,Zheng M,Jenkins S,Dicker IB,Krystal MR,Meanwell NA,Walker MA
Evidence	A series of heterocyclic pyrimidinedione-based HIV-1 integrase inhibitors was prepared and screened for activity against purified integrase enzyme and/or viruses modified with the following mutations within integrase: Q148R, Q148H/G140S and N155H.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation