|
Mutation Information
|
Mutation Site
|
G140S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Viral Reference
|
Q76353
|
|
Relevant Drug
|
raltegravir (RAL) |
Literature Information
|
PubMed PMID
|
31551948
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
Frontiers in microbiology |
|
Title
|
Raltegravir-Induced Adaptations of the HIV-1 Integrase: Analysis of Structure, Variability, and Mutation Co-occurrence. |
|
Author
|
Machado LA,Gomes MFDC,Guimarães ACR |
|
Evidence
|
This observation highlights the fact that T97A does not play a role impairing RAL binding but somehow compensates for the impacts of mutations Y143RC and N155H and Q148H + G140S.
|
|
|
HIV Mutation Detail Information